Effect of electrolytes on the sol–gel phase transitions in a Pluronic F127/carboxymethyl cellulose aqueous system: Phase map, rheology and NMR self-diffusion study

This investigation aims to obtain a thermosensitive platform useful for specific nanomedicine applications through the addition of suitable salts. An aqueous mixture consisting copolymer Pluronic F127 and sodium carboxymethyl-cellulose, in ratio 20/4 by weight, presence different concentrations Na2SO4, NaCl, NaSCN, was investigated using visual inversion tube approach estimate phase map, then characterized rheological measurements. The formation cubic liquid crystalline at temperatures higher than 37 °C suggested all systems. complex viscosity, decreases salts order Na2SO4 > NaCl NaSCN with more marked effect lower concentrations. Salt allows tune crowding NaCMC. For polymer sample containing 1H NMR self-diffusion experiments display non-mono-exponential decay echo signals F127, caused polydispersity commercial F127. properties along diffusion behaviour crystal micelles suggest that 0.07 mol/kg, sol-hard gel transition temperature around 35 °C, close body, may be biocompatible administer both hydrophobic hydrophilic drugs such as antibiotics, anticancer or growing factors. Synopsis: A simple thermoresponsive drug delivery: NaCMC NaCl.